Effectiveness Test of Ethanol Extract of Noni (Morinda citrifolia L.) Leaves as a Weight Loss Agent in Mice (Mus musculus)

Abstract

Obesity is a disorder characterized by excessive fat accumulation in the body, often caused by overconsumption of food. Obese individuals are at higher risk of developing degenerative diseases. One plant known to reduce obesity is Noni (Morinda citrifolia L.) plant. This plant contains flavonoid compounds that act as pancreatic lipase inhibitors and appetite suppressants, thus aiding in weight loss. This research aims to determine the effectiveness of ethanol extract of Noni (Morinda citrifolia L.) leaves as a weight loss agent in mice (Mus musculus). This research employs an experimental method. The anti-obesity effect test was conducted using male mice, divided into five treatment groups: Group I as the Negative Control Group (Na CMC 1%), Group II as the Positive Control Group (Orlistat), Group III as Test Group 1 (Dose 20 mg/kg BW), Group IV as Test Group 2 (Dose 30 mg/kg BW), and Group V as Test Group 3 (Dose 40 mg/kg BW). The results indicate that the ethanol extract of Noni (Morinda citrifolia L.) leaves contains secondary metabolites such as flavonoids, saponins, and tannins. The results indicate that the best effectiveness was observed in the group with a 40 mg/kg BW dose, though it was greater than the positive control group (Orlistat 120 mg).