PALUWALA: Jurnal Ilmu Kesehatan
type: channel
description: Paluwala is a term from the Gorontalo language that means "Source". This meaning holds great significance and serves as the fundamental basis for naming this journal, especially since it focuses on the field of health. As a "source," Paluwala symbolizes the origin or starting point of reliable information and knowledge. Therefore, this name reflects the journal's aim to be a trusted reference center for research, data, and advancements in health science. PALUWALA: Jurnal Ilmu Kesehatan is a scientific journal published by CV Airlangga Press, which aims to become a leading platform for publishing research and studies in the fields of health. This journal accepts high quality articles from a variety of scientific disciplines, including Medicine, Nursing, Public Health, Pharmachy, & Physiotherapy Before submission, you have to make sure that your paper is prepared using the PALUWALA: Jurnal Ilmu Kesehatan Template, has been carefully proofread and polished, and conformed to the Author Guidelines. Journal title PALUWALA: Jurnal Ilmu Kesehatan Initials PJIK Abbreviation Paluwala Jur. Ilmu Kes. Frequency 2 issues per year start from 2025: January & July Online ISSN 3090-0239 Editor-in-chief Gusti Pandi Liputo Publisher CV. Airlangga Press
publisher: CV. Airlangga Press
language: en
publication name: PALUWALA: Jurnal Ilmu Kesehatan
issn: 3090-0239
items: Differences in the Effectiveness of Reducing Organophosphate Pesticide Residues in Chili Peppers Using Lime and Hot Water Soaking
items: Determinant Analysis of Premarital Sexual Knowledge among Adolescents at SMP Negeri 9 Gorontalo
items: NUTRITIONAL CONTENT ANALYSIS AND ORGANOLEPTIC TESTING OF SORGHUM-BASED COOKIES AS A SOLUTION FOR SUPPLEMENTARY FOOD PROVISION FOR TODDLERS
items: Analysis of the Relationship Between Pesticide Exposure Frequency and Personal Protective Equipment with Contact Dermatitis Complaints in Farmers
items: Unveiling Major Sesquiterpenes in Patchouli Leaf Essential Oil Using GC-MS
items: The Relationship Between Contact Duration and Detergent Type with Incidence of Contact Dermatitis in Housewives
items: Density of Aedes aegypti Larvae Based on the Entomological Index in Huidu Village, West Limboto District
items: The Effect of Progressive Muscle Relaxation on Blood Pressure in Hypertensive
items: Sacha Inchi Milk Development as Antioxidant Functional Beverage through Community Empowerment in Tabongo Timur
items: Food Consumption Patterns of Students in Free Nutritious Meals Program: A Study in Gorontalo City
items: In Silico Study Of Molecular Docking Of Compounds FromMeniran (Phyllanthus Niruri) On Angiotensin Converting Enzyme (Ace) Receptor As Potential Antihypertensive Agents
items: Overview of Antibiotic Utilization for Surgical Patients Using ATC/DDD and DU90% Methods at Otanaha Hospital
items: Correlation Between Sitting Duration, Consumption Patterns and Daily PhysicalActivity with Nutritional Status Among Coffee Shop Customers at Nuansa by Lawa
items: Patient Adherence and Adverse Effects Of Antituberculosis Drugs: A Cross-Sectional Study in the Gorontalo Region
items: Formulation and Evaluation of Antibacterial Activity of Impatiens balsamina Leaf Cream Against Propionibacterium acnes
items: Herbal Medicine Safety: Comparative Evaluation of Adverse Drug Reactions in Two Subdistrict, Gorontalo City
items: Analysis of Family Education Program on Adolescent Reproductive Health
items: In Silico Study of Asparagus officinalis Plant Compounds Against Estrogen Receptor Alpha (ER-α) as a Candidate for Breast Anticancer
items: Pharmacoinformatics Innovation: A Web-Based Calculator to Enhance Pharmaceutical Practice and Education
items: The Potential of Microalgae from Bone River Gorontalo as an Antioxidant
items: Pharmacokinetic and Bioavailability Profile of Hyptis capitata Jacq Flavonoids: A Scientific Perspective on Traditional
items: Formulation and Physical Evaluation of Ethanol Gel Extract of Okra Fruit (Abelmoschus esculentus L. Moench) From Parepare City
items: Toxic Effects of Prenylated Flavone Compounds from the Chloroform Fraction of Kaledang (Artocarpus Lanceifolius Roxb.) Stem Bark In Vitro
items: Effectiveness Test of Ethanol Extract of Noni (Morinda citrifolia L.) Leaves as a Weight Loss Agent in Mice (Mus musculus)
items: Connecting Family Support with Self-Care for People with Diabetes Mellitus
items: HUBUNGAN PERAN ORANG TUA DENGAN KECEMASAN ANAK SAAT DI RAWAT DI RUMAH SAKIT UMUM DAERAH OTANAHA KOTA GORONTALO
items: Pengaruh ROM Terhadap Kejadian Fatigue Pada Pasien Hemodialisa
items: GAMBARAN TINGKAT PENGETAHUAN TENTANG BAHAYA MEROKOK PADA PASIEN TB PARU DI PUSKESMAS KOTA SELATAN
items: HUBUNGAN ILLNESS PERCEPTION DENGAN KUALITAS HIDUP PADA PENDERITA DIABETES MELITUS TIPE II DI WILAYAH KERJA PUSKESMAS KABILA
items: Gambaran Pengetahuan Perawat Tentang Penatalaksanaan Pertolongan Pertama Pada Kecelakaan Lalu Lintas Di Puskesmas Kota Gorontalo

Differences in the Effectiveness of Reducing Organophosphate Pesticide Residues in Chili Peppers Using Lime and Hot Water Soaking
type: item
description: The use of organophosphate pesticides in agriculture, particularly on bird’s eye chili (Capsicum frutescens L.), may leave harmful residues that can cause neurological disorders, liver damage, and even cancer if consumed continuously. This study aimed to analyze the difference in effectiveness between lime solution and hot water immersion in reducing organophosphate pesticide residues on bird’s eye chili. The research employed a quasi-experimental design with immersion times of 6, 7, and 8 minutes. Residue analysis was conducted using a spectrophotometric method. The results showed that lime immersion reduced residue levels from 1.487 mg/kg to 1.459 mg/kg (6 minutes), 1.205 mg/kg (7 minutes), and 0.972 mg/kg (8 minutes), but did not reach the safe limit set by SNI (0.5 mg/kg). In contrast, hot water immersion significantly reduced residues to 0.130 mg/kg (6 minutes), 0.037 mg/kg (7 minutes), and 0.004 mg/kg (8 minutes), all of which were below the maximum residue limit. Statistical tests indicated a significant difference between the two treatments. It can be concluded that hot water immersion is more effective than lime solution in reducing organophosphate pesticide residues on bird’s eye chili. These findings provide practical recommendations for reducing pesticide exposure risk through simple household processing methods.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: pesticides
  topic: keywords
subject: organophosphates
  topic: keywords
subject: bird's eye chili
  topic: keywords
subject: lime
  topic: keywords
subject: hot water
  topic: keywords
creator: Nandi Putri Rahayu Hatibi
creator: Irwan Irwan
creator: Ayu Rofia Nurfadillah
rights: Copyright (c) 2025 Nandi Putri Rahayu Hatibi, Irwan, Ayu Rofia Nurfadillah (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 287
ending page: 291

Determinant Analysis of Premarital Sexual Knowledge among Adolescents at SMP Negeri 9 Gorontalo
type: item
description: Premarital sexual knowledge among adolescents is an important aspect in preventing risky behaviors that may affect reproductive health. This study aims to analyze the factors influencing premarital sexual knowledge among adolescents at SMP Negeri 9 Gorontalo City, with a focus on media exposure, peer influence, and self-defense. The research employed a quantitative method with a correlational design using a cross-sectional approach. The study population consisted of all ninth- grade students at SMP Negeri 9 Gorontalo City, totaling 81 respondents, selected through a total sampling technique. The research instrument was a questionnaire, and data analysis was conducted using the Chi-Square test. The findings revealed that 27.2% of adolescents had good premarital sexual knowledge, while 72.8% had moderate knowledge. Respondents with good utilization of social media accounted for 25.9%, those with positive peer influence were 25.9%, and those with strong self-defense were 39.5%. Statistical tests indicated significant relationships between premarital sexual knowledge and media exposure (p=0.000), peer influence (p=0.014), and self-defense (p=0.000). It can be concluded that social media, peer influence, and self-defense are significantly associated with adolescents’ level of premarital sexual knowledge. Therefore, the active role of schools, teachers, and parents is required to provide comprehensive sexual education and create a supportive social environment.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Premarital sexual knowledge
  topic: keywords
subject: adolescents
  topic: keywords
subject: social media
  topic: keywords
subject: peers
  topic: keywords
subject: self-defense
  topic: keywords
creator: Fitra Handayani Tangahu
creator: Herlina Jusuf
creator: Nikmatisni Arsad
rights: Copyright (c) 2025 Fitra Handayani Tangahu, Herlina Jusuf, Nikmatisni Arsad (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 268
ending page: 273

NUTRITIONAL CONTENT ANALYSIS AND ORGANOLEPTIC TESTING OF SORGHUM-BASED COOKIES AS A SOLUTION FOR SUPPLEMENTARY FOOD PROVISION FOR TODDLERS
type: item
description: Cookies are a snack generally made from wheat flour, butter, eggs, and powdered milk. Sorghum, rich in protein and fiber, is one solution for supplementary feeding for toddlers. The research question is how the protein, carbohydrate, fat, and fiber content of sorghum cookies, and the organoleptic acceptability of sorghum cookies, are determined. The objectives of this study were to analyze the protein, carbohydrate, fat, and fiber content, as well as to evaluate the organoleptic properties of sorghum cookies. The research was descriptive, using the Kjeldahl test, Soxhlet extractor, gravimetry, and titrimetry to determine the protein, carbohydrate, fat, and fiber content, as well as the organoleptic acceptability of the cookies. Twenty panelists were students majoring in nutrition, Public Health, Gorontalo State University. Data were analyzed descriptively, with the primary goal of creating an objective picture or description of a situation. The results of the study showed that sorghum cookies contain 7.21% protein. The carbohydrate content is 43.10%. The fat content is 18.70%. The fiber content is 5.76%. Based on the results of the organoleptic test, it was found that the percentage value of the panelists who liked the appearance was 85%, in terms of aroma, it was found that the percentage value of those who liked it was 90%, in terms of texture, it was found that the percentage value of those who liked it was 50%, and in terms of taste, it was found that the percentage value of those who liked it was 90%. It is recommended to conduct further research on other nutritional content, and test the durability of cookies to determine how long the product is durable and suitable for consumption.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Cookies
  topic: keywords
subject: Nutritional content
  topic: keywords
subject: , Organoleptic
  topic: keywords
subject: , Sorghum.
  topic: keywords
creator: Muhamad Al-Fatah Nastain
creator: Sunarto Kadir
creator: Ayu Rofia Nurfadillah
rights: Copyright (c) 2025 Muhamad Al-Fatah Nastain, Sunarto Kadir, Ayu Rofia Nurfadillah (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 274
ending page: 279

Analysis of the Relationship Between Pesticide Exposure Frequency and Personal Protective Equipment with Contact Dermatitis Complaints in Farmers
type: item
description: Occupational Safety and Health are protection efforts in terms of health, safety and comfort provided to workers/laborers, the environment or other people around the workplace. One of the employment sectors that recruits a lot of workers in Indonesia is the informal sector. The informal sector is one of the industries far from the Occupational Health and Safety (K3) culture. The implementation of K3 in the informal sector is still rarely carried out, this occurs because not all industries register with the UKK Post (Occupational Health Unit) so they do not receive education related to occupational safety and health and are not monitored for the occurrence of work accidents and occupational diseases in informal industries (Romas & Kumala, 2024) . One informal sector that is far from the K3 culture is the agricultural sector. The rate of work accidents in the agricultural sector in Indonesia is relatively high compared to other industries (Ella, 2023) . This needs special attention considering that the majority of the population works in the agricultural sector and the large contribution of this sector to the national economy (Haerani, 2010). The role of the agricultural sector is as a source of basic necessities, clothing and housing, providing employment for the majority of the population, contributing to high national income, providing foreign exchange for the country and having a high economic multiplier effect with low dependence on imports (multiplier effect), namely the input-output linkages between industries, consumption and investment. With consistently positive growth. This study used a quantitative method with an analytical survey research design with 59 farmers diagnosed with contact dermatitis, then the data was analyzed using the Chi-Square test. The results of the analysis of this research show that there is a statistical relationship between complaints of contact dermatitis and the frequency of pesticide exposure and personal protective equipment.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: K3
  topic: keywords
subject: contact dermatitis
  topic: keywords
subject: pepticid
  topic: keywords
creator: Anggriani Rajiku
creator: Herlina Jusuf
creator: Putri Ayuningtias Mahdang
rights: Copyright (c) 2025 Anggriani Rajiku, Herlina Jusuf, Putri Ayuningtias Mahdang (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 258
ending page: 262

Unveiling Major Sesquiterpenes in Patchouli Leaf Essential Oil Using GC-MS
type: item
description: Patchouli (Pogostemon cablin Benth.) is a tropical plant widely recognised as the main source of patchouli oil, an essential oil with high economic and pharmaceutical value. This study aimed to identify the chemical constituents of patchouli leaf essential oil and determine its major compounds. Extraction was performed using solvents of different polarities, followed by analysis with Gas Chromatography–Mass Spectrometry (GC-MS). The results revealed five dominant compounds: Bicyclo[5.3.0]decane, 2-methylene-5-(1-methylvinyl)-8-methyl (19.99%), Aromandendrene (12.04%), Naphthalene, decahydro-4a-methyl-1-methylene-7 (9.20%), Caryophyllene (7.29%), and Valerena-4,7(11)-diene (6.87%). These compounds play an important role in both the aroma and biological activities of patchouli oil. Methanol, as a polar solvent, produced the highest yield (10%), while n-hexane yielded the lowest (2%). The findings confirm the potential of patchouli essential oil as a natural source for pharmaceutical, cosmetic, and aromatherapy applications
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Essential oil
  topic: keywords
subject: Pogostemon cablin Benth
  topic: keywords
subject: Patchouli
  topic: keywords
subject: GC-MS
  topic: keywords
creator: Muhammad Taupik
creator: Mohamad Adam Mustapa
creator: Fahmi As Radjak
creator: A. Mu'thi Andy Suryadi
creator: Mohamad Aprianto Paneo
rights: Copyright (c) 2025 Muhammad Taupik, Mohamad Adam Mustapa, Fahmi As Radjak, A. Mu'thi Andy Suryadi, Mohamad Aprianto Paneo (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 252
ending page: 257

The Relationship Between Contact Duration and Detergent Type with Incidence of Contact Dermatitis in Housewives
type: item
description: Disease skin is condition Where moment layer outside body experience problem Good irritation and inflamed . Dermatitis is reaction inflammation polymorphic involving the epidermis and dermis, response skin depending on the type material chemicals in contact with skin , duration of contact , frequency usage , and types detergent used by each individual . Research objectives This For analyze relationship between length of contact and type detergent with complaints of contact dermatitis in mothers House stairs in the work area Community Health Center Paguyaman .Types of research This is Quantitative with Design research of a nature analytic with approach Cross Sectional . Research sample totaling 70 mothers House selected stairs​ use technique consecutive sampling . Instruments in the study This is questionnaire NOSQ-2002/SHORT For analyze relationship between length of contact and type detergent with contact dermatitis complaints .Based on results study known that from 70 mothers House stairs , there are long-term contact relationship detergent with complaints of contact dermatitis in mothers House ladder obtained p value = 0.033 < α (0.05). There is connection type detergent used​ with complaints of contact dermatitis in mothers House ladder obtained p value = 0.014 < α (0.05). For mothers House ladder expected more be careful in use detergent , with method use sarong hand moment wash clothes For minimize contact direct with detergent , avoid use detergent in excessive amounts so that the residue No left behind , and reduce frequency use detergent every the day.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Contact Dermatitis
  topic: keywords
subject: Contact Duration
  topic: keywords
subject: Types of Detergent
  topic: keywords
creator: Moh. Rivai Nakoe
creator: Laksmyn Kadir
rights: Copyright (c) 2025 Moh. Rivai Nakoe, Laksmyn Kadir (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 263
ending page: 267

Density of Aedes aegypti Larvae Based on the Entomological Index in Huidu Village, West Limboto District
type: item
description: Dengue Hemorrhagic Fever (DHF) remains a significant public health problem as it frequently causes outbreaks and poses a risk of death. According to the World Health Organization (WHO) report as of April 30, 2024, more than 7.6 million dengue cases have been recorded worldwide, including 3.4 million confirmed cases, over 16,000 severe cases, and more than 3,000 deaths. This study is an observational research with a descriptive design aimed at assessing the density level of Aedes aegypti vectors through the calculation of the House Index (HI), Container Index (CI), Breteau Index (BI), Density Figure (DF), and Larvae-Free Index (ABJ). The examination was carried out by identifying the presence of larvae in water-holding containers without collecting larval samples. The results showed that the HI was 23% from 100 inspected houses, the CI was 2.9% from 800 containers examined, and the BI was 23% from 100 houses. Based on these findings, the Density Figure in Huidu Village, Limboto Barat Subdistrict, was 3.3, categorized as a Yellow Zone, which indicates a moderate level of vector transmission and requires vigilance. Mosquito breeding site eradication (PSN) efforts need to be strengthened through continuous 3M Plus activities, community empowerment in maintaining environmental cleanliness, and strengthening the role of larva monitoring cadres (Jumantik) to routinely inspect larvae presence in order to reduce the risk of dengue transmission.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Dengue Hemorrhagic Fever
  topic: keywords
subject: Container Indeks
  topic: keywords
subject: Breteau Index
  topic: keywords
subject: Density Figu
  topic: keywords
creator: Ayu Rofiah Nurfadillah
creator: Reinaldi Julfirman Saleh
creator: Sunardi Sunardi
rights: Copyright (c) 2025 Ayu Rofiah Nurfadillah, Reinaldi Julfirman Saleh, Sunardi (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 245
ending page: 251

The Effect of Progressive Muscle Relaxation on Blood Pressure in Hypertensive
type: item
description: Hypertension is a non-communicable disease that is a major cause of morbidity and mortality worldwide, including in Indonesia. The elderly are the most vulnerable group, given that the aging process is accompanied by decreased organ function and a less active lifestyle. Hypertension management is not limited to pharmacological therapy, but can also be carried out with non-pharmacological approaches, one of which is through progressive muscle relaxation. This technique is considered effective in helping to lower blood pressure naturally, safely, and can be done independently. This study aims to determine the effect of progressive muscle relaxation therapy on blood pressure in elderly people with hypertension in the work area of the UPTD Samaenre Community Health Center, Sinjai Regency. The study design used a pre-experimental with a pre-test and post-test approach. The sample consisted of 18 elderly people with hypertension selected using a purposive sampling technique from a total population of 30 people. Blood pressure was measured using a sphygmomanometer, and data were analyzed using a paired sample t-test. The results showed a decrease in blood pressure after the intervention. The average systolic blood pressure before therapy was 145.89 mmHg and decreased to 143.78 mmHg. Meanwhile, diastolic blood pressure decreased from 87.56 mmHg to 86.44 mmHg. The statistical test results showed a significance value of p = 0.000 (p < 0.05), indicating a significant effect of progressive muscle relaxation therapy on blood pressure reduction.Conclusion: Progressive muscle relaxation therapy has been proven to be effective in reducing blood pressure in hypertensive elderly and can be used as a safe, inexpensive, and easy-to-implement non drug intervention in primary health care.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Hypertension
  topic: keywords
subject: Elderly
  topic: keywords
subject: Progressive Muscle Relaxation
  topic: keywords
subject: Blood Pressure
  topic: keywords
subject: Non-Pharmacological
  topic: keywords
creator: Zainab Zainab
creator: Faridah Said
rights: Copyright (c) 2025 Zainab Zainab, Faridah Mohd Said (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 237
ending page: 244

Sacha Inchi Milk Development as Antioxidant Functional Beverage through Community Empowerment in Tabongo Timur
type: item
description: Sacha Inchi milk represents a promising plant-based functional beverage with high nutritional value and potential antioxidant activity. This study aimed to develop Sacha Inchi milk formulations as a community-based innovation in Tabongo Timur, focusing on optimizing physicochemical properties, sensory acceptance, antioxidant capacity, and the integration of participatory empowerment. The experimental design employed a Completely Randomized Design with a single factor, namely emulsifier concentration, using carboxymethyl cellulose and xanthan gum at three levels (0.5%, 0.8%, and 1.2%), alongside a control without emulsifier. Each formulation was prepared from Sacha Inchi seeds by soaking, cleaning, blending with water, boiling, filtering, sweetening, emulsifier addition, pasteurization, and cold storage. Seven treatments with three replications each were analyzed for viscosity, density, pH, protein content, sensory attributes, and antioxidant activity. Parallel to product development, Participatory Action Research was implemented through capacity building, collaborative production, and market facilitation with farmers’ groups, women’s groups, and Village-Owned Enterprises. The results showed that emulsifiers significantly enhanced viscosity (from 57.9 mPas in the control to 302 mPas with carboxymethyl cellulose 1.2%) and improved density stability (1.020 g/mL). pH values increased slightly (6.30–7.34), while protein content was maintained across treatments (11.02–14.13%). Sensory evaluation revealed no significant differences in taste or color, but texture improved notably with higher emulsifier concentrations, especially xanthan gum at 1.2%. Antioxidant activity assessed by the DPPH method indicated moderate capacity, with LC₅₀ values of 145.6 ppm for carboxymethyl cellulose 1.2% and 162.3 ppm for xanthan gum 1.2%. Community empowerment outcomes showed significant improvements in hygienic processing, quality control, business management, gender-inclusive participati…
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Sacha Inchi milk
  topic: keywords
subject: functional beverage
  topic: keywords
subject: antioxidant activity
  topic: keywords
subject: community empowerment
  topic: keywords
creator: Yuszda K. Salimi
creator: Yoyanda Bait
creator: Arwin Huruji
creator: Mohammad Isra
creator: Ningrayati Amali
creator: Umar Sako Baderan
rights: Copyright (c) 2025 Yuszda K. Salimi, Yoyanda Bait, Arwin Huruji, Mohammad Isra, Ningrayati Amali, Umar Sako Baderan (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 224
ending page: 236

Food Consumption Patterns of Students in Free Nutritious Meals Program: A Study in Gorontalo City
type: item
description: The Free Nutritious Meal Program (MBG) in Gorontalo City is a government initiative to provide healthy and nutritious meals for students from elementary to high school. This study aims to analyze student food consumption patterns within the MBG program. The method used was a quantitative descriptive design with a cross-sectional approach, involving a sample of 150 students from three schools participating in the MBG program. The results showed that vegetables were the most frequently leftover food, reaching 86 students (57.3%). The majority of students (85 students) rated mealtimes as neutral, indicating that the current schedule is suboptimal. The highest frequency of food was in the "sometimes" categsory, with 62 students (41.3%). The comfort of the dining area was also in the "average" category, with 62 students (41.3%). Therefore, improving the dining environment is expected to improve the student experience. In terms of hunger, 80 students (53.3%) felt sometimes hungry when food was served, while 75 students (50.0%) experienced no disturbances while eating. The MBG program has had a positive impact, but challenges remain related to consumption patterns. Innovations in vegetable presentation and better adjustments to meal times are crucial to increasing food consumption and reducing food waste
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: food_consumption_patterns
  topic: keywords
subject: Free_Nutritious_Meal_Program
  topic: keywords
subject: students
  topic: keywords
subject: plate_waste
  topic: keywords
creator: Tri Septian Maksum
creator: Sarinah Basri K
creator: Vidya Avianti Hadju
creator: Fitriani Rahmatismi Blongkod
rights: Copyright (c) 2025 Tri Septian Maksum, Sarinah Basri K, Vidya Avianti Hadju, Fitriani Rahmatismi Blongkod (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 188
ending page: 193

In Silico Study Of Molecular Docking Of Compounds FromMeniran (Phyllanthus Niruri) On Angiotensin Converting Enzyme (Ace) Receptor As Potential Antihypertensive Agents
type: item
description: Hypertension is one of the leading non-communicable diseases with increasing prevalence and is a major cause of global mortality. The Angiotensin-Converting Enzyme (ACE) is a primary target in antihypertensive therapy, where its inhibition can help lower blood pressure. Phyllanthus niruri, commonly known as meniran, is known to contain various bioactive compounds with potential as natural antihypertensive agents. This study aims to evaluate the potential of 32 active compounds from Phyllanthus niruri as ACE inhibitor candidates through an in silico approach using Lipinski’s Rule of Five and molecular docking. The compound structures were obtained from the PubChem database and assessed for pharmaceutical feasibility using Lipinski’s Rule. Molecular docking was performed against the ACE enzyme (PDB ID: 1J36) using AutoDock Vina, with lisinopril as the positive control. The results showed that 16 compounds fully met all Lipinski's criteria, while the remaining compounds violated one or two parameters. Docking analysis revealed that 12 compounds exhibited stronger binding affinity than lisinopril (−10.3 kcal/mol), with rutin (−12.0 kcal/mol) and fisetin 4′- glucoside (−11.8 kcal/mol) showing the highest affinities. These findings suggest that several active compounds from Phyllanthus niruri possess promising potential as ACE inhibitors. Although some compounds did not fully comply with Lipinski’s Rule, their high binding affinities still offer significant opportunities for further development as natural oral antihypertensive agents.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Phyllanthus niruri
  topic: keywords
subject: Lipinski’s Rule of Five
  topic: keywords
subject: Molecular Docking
  topic: keywords
subject: ACE
  topic: keywords
subject: Hypertension
  topic: keywords
subject: In Silico
  topic: keywords
creator: Amar Maruf
creator: La Ode Aman
creator: Ariani Hutuba
rights: Copyright (c) 2025 Amar Maruf, La Ode Aman, Ariani Hutuba (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 215
ending page: 223

Overview of Antibiotic Utilization for Surgical Patients Using ATC/DDD and DU90% Methods at Otanaha Hospital
type: item
description: One of the medical actions to cure a disease is surgery, but in this action the patient is prone to infection. Antibiotics are often used to prevent infection. According to the Antimicrobial Resistance in Indonesia (AMRIN) study, 42% of antibiotic use is indicated to be inappropriate in surgical patients which causes the risk of resistance. To reduce the incidence of antibiotic resistance, the World Health Organization (WHO) recommends the Anatomical Therapeutic Chemical (ATC)/Defined Daily Dose (DDD) method to evaluate antibiotic use and this method can also be used in conjunction with the 90% Drug Utilization (DU) method. This study aims to determine the description of antibiotic use in surgical patients using the ATC/DDD and DU 90% methods at Otanaha Hospital, Gorontalo City. This research design is descriptive quantitative research with retrospective data collection. This research data is all medical record data of surgical patients who use antibiotics and have met the inclusion and exclusion criteria in the period January-December 2024. A total sample of 474 medical record data was obtained. The results showed that the total use of antibiotics was 97.11 DDD/100 bed-days, with the highest DDD value in the use of ceftriaxon antibiotics 45.88 DDD/100 bed-days and the least was azithromicin 0.12 DDD/100 bed-days and antibiotics included in the DU 90% segment were ceftriaxone antibiotics, metronidazole by oral and parenteral routes, cefoperazone, meropenem and cefixime. In conclusion, the consumption rate of antibiotic use in surgical patients at Otanaha Regional General Hospital is still quite high. Therefore, it is hoped that the results of this study can help the hospital in monitoring the use of antibiotics in surgical patients so as to increase the effectiveness of their use.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Antibiotics
  topic: keywords
subject: ATC/DDD_DU 90%
  topic: keywords
subject: Surgical Patients
  topic: keywords
creator: Nurmiati I. Panu
creator: Nur Rasdianah
creator: Andi Makkulawu
rights: Copyright (c) 2025 Nurmiati I. Panu, Nur Rasdianah, Andi Makkulawu (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 208
ending page: 214

Correlation Between Sitting Duration, Consumption Patterns and Daily PhysicalActivity with Nutritional Status Among Coffee Shop Customers at Nuansa by Lawa
type: item
description: Changes in modern society’s lifestyle have increased sedentary activities, such as sitting for long periods in coffee shops, and have also influenced dietary patterns and physical activity, which in turn affect nutritional status. The research problem in this study is whether there is an association between sitting duration, dietary patterns, and daily physical activity with the nutritional status of coffee shop customers. This study aims to determine the association between sitting duration, dietary patterns, and daily physical activity with the nutritional status of customers at Nuansa by Lawa Coffee Shop in Gorontalo City. This research is a quantitative analytic study using a cross-sectional approach. The population consists of coffee shop customers aged 18–25 years, with a total sample of 188 respondents obtained through accidental sampling techniques. Data were collected using the FFQ and GPAQ questionnaires along with Body Mass Index (BMI) measurements. Data analysis was conducted using the ChiSquare test. The statistical analysis revealed that sitting duration obtained (p = 0.022 < 0.05), dietary patterns obtained (p = 0.000 < 0.05), and physical activity obtained (p = 0.840 > 0.05). Based on these findings, sitting duration and dietary patterns were significantly associated with nutritional status, while physical activity was not significantly associated. It is expected that these findings can help raise public awareness, especially among coffee shop customers, to maintain dietary patterns and regulate sitting time to prevent nutritional status disorder
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: antibacterial
  topic: keywords
subject: cream
  topic: keywords
subject: impartiensbalsmina
  topic: keywords
subject: Propionibacteriumacnes
  topic: keywords
creator: Fatturahman Wahyudi Mokoagow
creator: Sunarto Kadir
creator: Vidya Avianti Hadju
rights: Copyright (c) 2025 Fatturahman Wahyudi Mokoagow, Sunarto Kadir, Vidya Avianti Hadju (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 280
ending page: 286

Patient Adherence and Adverse Effects Of Antituberculosis Drugs: A Cross-Sectional Study in the Gorontalo Region
type: item
description: Tuberculosis (TB) remains a global public health challenge, especially in Indonesia, which ranks third among countries with the highest TB burden worldwide. This study aims to describe patient adherence and the incidence of adverse effects from anti-TB drugs (ATDs) in the Gorontalo region. A cross-sectional design was employed involving 259 TB patients from 11 primary health centers undergoing Category I and II treatment. Data were collected using direct observation, the Morisky Medication Adherence Scale (MMAS-8), and patient self-reports of adverse drug reactions. The results showed that 82.24% of patients demonstrated high adherence, although more than 30% experienced side effects such as malaise, nausea, headache, and dizziness. The majority of patients were female, of productive age, had secondary-level education, and worked in informal sectors. Despite the prevalence of side effects, the effectiveness of the DOTS strategy and strong social support appeared to contribute to high adherence. These findings highlight the importance of education, side-effect monitoring, and community-based approaches to improve TB treatment outcomes.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Tuberculosis_Medication_Adherence
  topic: keywords
subject: Adverse_Drug_Reactions
  topic: keywords
subject: Gorontalo
  topic: keywords
creator: Madania Madania
creator: Mohamad Reski Manno
rights: Copyright (c) 2025 Madania Madania, Mohamad Reski Manno (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 194
ending page: 200

Formulation and Evaluation of Antibacterial Activity of Impatiens balsamina Leaf Cream Against Propionibacterium acnes
type: item
description: Treatment of acne can be done by administering antibiotics orally or topically. Topical preparations have the advantage of longer contact time with the skin surface, allowing the active substance to be absorbed optimally. One alternative that can be used to prevent bacterial resistance is to utilize secondary metabolite compounds found in plants. Water henna (Impatiens balsamina) is one of the plants that has antibacterial activity against Propionibacterium acnes. This study aims to determine the formulation, evaluation and test the antibacterial activity of cream preparations of ethanol extract of water henna leaves. This research begins with the preparation of extracts using the maceration meth od, after which testing the antibacterial activity of extracts and base optimization is carried out. The base was evaluated including organoleptic test, homogeneity, pH, spreadability, adhesiveness, viscosity. The best base was selected to formulate the water henna leaf extract into a cream dosage form. The cream was formulated with variations of 20%, 25% and 30% extract concentrations. Antibacterial activity test was conducted using disc diffusion method (Kirby-Bauer). The results showed that all formulas had antibacterial activity with a strong category against Propionibacterium acnes, with inhibition power successively equal to F1 (11.07 mm), F2 (11.67 mm) and F3 (12.05 mm). Based on physical evaluation, all formulas generally meet the requirements, although F3 is not homogeneous and its spreadability has not met the requirements..
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Antibacterial
  topic: keywords
subject: Cream_impatiens_balsamina
  topic: keywords
subject: Propionibacterium_acnes
  topic: keywords
creator: Nur Ain Thomas
creator: Trista Ismail
creator: Mahdalena Pakaya
rights: Copyright (c) 2025 Nurain Thomas, Trista Ismail, Mahdalena Sy. Pakaya (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 201
ending page: 207

Herbal Medicine Safety: Comparative Evaluation of Adverse Drug Reactions in Two Subdistrict, Gorontalo City
type: item
description: Amid the growing trend of herbal medicine consumption in Indonesia, it is essential to understand the potential Adverse Drug Reactions (ADRs) that may arise across various communities. Gorontalo, a region rich in biodiversity, continues to widely utilize herbal medicines in daily practices. This study aimed to evaluate the profile of Adverse Drug Reactions (ADRs) among herbal medicine users in the Sipatana and Kota Utara sub-districts of Gorontalo City. A descriptive observational approach was employed, with data collected through direct interviews with 194 respondents, comprising 97 participants from each sub-district. Collected data included demographic characteristics, types of herbal medicines used, and clinical manifestations of ADRs. Quantitative analyses were conducted to determine the frequency, ADR categories based on causality, and causal relationships according to the Naranjo ADR Probability Scale. The results indicated that most respondents were of productive age (31–50 years), predominantly female and housewives. Among the nine reported ADR cases, 22.3% were classified as possible, 44.4% as probable, and 33.3% as definite. The herbs most frequently associated with ADRs included garlic, moringa leaves, Peperomia pellucida, Kayu Bajakah, Clinacanthus nutans, and soursop leaves. The most common manifestations involved the gastrointestinal system, such as epigastric pain, colic, diarrhea, as well as certain metabolic and hypoglycemic effects. The study emphasizes the importance of individual factors, dosage, duration of use, and herbal combinations in determining ADR risk. These findings underscore the need for patient education on safe herbal use, appropriate clinical monitoring, and consultation with healthcare professionals before combining multiple herbs. Further research is recommended to examine interactions between herbs and conventional drugs and to develop community-based herbal pharmacovigilance systems. Consequently, this study provides a scienti…
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: ADR’s
  topic: keywords
subject: Naranjo
  topic: keywords
subject: Gorontalo
  topic: keywords
creator: Teti Sutriyati Tuloli
creator: Aprianto Paneo
creator: Robert Tungadi
creator: Fahira Rais
creator: Putery Datungsolang
creator: Safitri Bahtiar
rights: Copyright (c) 2025 Teti Tuloli, Mohamad Aprianto Paneo, Robert Tungadi, Fahira Rais, Putery Fauzia Datungsolang, Safitri Ekaputri Bahtiar (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 165
ending page: 176

Analysis of Family Education Program on Adolescent Reproductive Health
type: item
description: Efforts to promote and prevent reproductive health problems also need to be directed at adolescence, a transitional period from childhood to adulthood, during which rapid changes in body shape and function occur. Information dissemination, counseling, and clinical services need to be enhanced to address adolescent reproductive health issues. This type of research is a quasi-experimental study using a one-group pre-test and post-test design. The population in this study consisted of families with adolescents at Lawawoi Community Health Center (UPT) South Sulawesi, totaling 30 respondents. The sample size was 30 respondents, selected using purposive sampling techniques. Data collection was carried out using a questionnaire. Data analysis was performed with the help of SPSS version 20 using the Wilcoxon test, with a significance level of p < 0.05. The results of the study showed a significant impact of family education on adolescent reproductive health, with a p-value of 0.021 (α < 0.05). The conclusion of this study is that there is an impact of the Family Education Program on Adolescent Reproductive Health at Lawawoi Community Health Center (UPT) South Sulawesi. It is hoped that families with adolescents can provide education to help improve adolescent reproductive health.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Family_Education
  topic: keywords
subject: Adolescent_Reproductive_Health
  topic: keywords
creator: Meriem Meisyaroh Syamson
creator: Tukimin Bin Sansuwito
rights: Copyright (c) 2025 Meriem Meisyaroh Syamson, Tukimin Bin Sansuwit (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 183
ending page: 187

In Silico Study of Asparagus officinalis Plant Compounds Against Estrogen Receptor Alpha (ER-α) as a Candidate for Breast Anticancer
type: item
description: Breast cancer is the most prevalent type of cancer and the leading cause of cancer-related death in women worldwide. The limitations of conventional therapies, such as the serious side effects of chemotherapy, drive the search for safer and more effective alternative treatments. Asparagus officinalis is known to contain bioactive compounds with potential anticancer properties. This study aimed to evaluate the potential of compounds from A. officinalis as oral drug candidates through an analysis of pharmaceutical feasibility based on Lipinski's Rule, pharmacokinetic and toxicity profiles, and modeling of their interaction with the estrogen receptor alpha (ER-α) using molecular docking. From 116 identified compounds, 64 satisfied Lipinski's Rule, and most showed good pharmacokinetic and toxicity profiles. The molecular docking results revealed that 19 compounds had a strong binding affinity (–7.09 to –9.59 kcal/mol). Catechin and 3PGPC showed the strongest affinity, closely approaching that of the comparative ligand, 4-hydroxytamoxifen (–9.98 kcal/mol). The interaction of these two compounds with key ER-α residues and the absence of hydrogen bonding with the His524 residue indicate that they act as antagonists against ER-α, which can inhibit the proliferation of breast cancer cells. These findings suggest that catechin and 3PGPC have the potential to be alternative ligands for ER-α and are worthy of further investigation as candidates for natural-based breast cancer drugs.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Breast_Cancer
  topic: keywords
subject: Asparagus_officinalis
  topic: keywords
subject: Estrogen_Receptor_Alpha_(ER−α)
  topic: keywords
subject: Molecular Docking
  topic: keywords
creator: Astrid Ismail
creator: Mohamad Adam Mustapa
creator: La Ode Aman
creator: Ariani Hutuba
rights: Copyright (c) 2025 Astrid Ismail, Mohamad Adam Mustapa, La Ode Aman, Ariani Hutuba (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 153
ending page: 164

Pharmacoinformatics Innovation: A Web-Based Calculator to Enhance Pharmaceutical Practice and Education
type: item
description: This study aimed to develop and evaluate a web-based pharmaceutical calculator designed to enhance pharmaceutical education and professional practice by providing accurate and efficient pharmacological calculations. The objective was to create a customizable, user-friendly, and open- access tool that assists pharmacy students and professionals in performing complex pharmacological computations, ultimately improving learning outcomes and reducing medication errors in clinical practice. Utilizing a Design-Based Research (DBR) methodology, the research involved three phases: requirements elicitation, system development using low-code tools, and usability assessment. The application was developed using WordPress CMS with the Elementor plugin to ensure functionality and a user-centered interface design. A usability study, employing the System Usability Scale (SUS), was conducted, with feedback collected from pharmacy students and practitioners. The results showed high user acceptability and satisfaction, with most respondents finding the calculator easy to use and effective in both academic learning and clinical tasks. The tool significantly reduced human error, improved understanding of pharmacological concepts, and simplified complex dosage calculations. In conclusion, the web-based pharmaceutical calculator successfully bridges the gap between theoretical knowledge and practical application, contributing to safer pharmaceutical practices and enhanced pharmacological education. The tool reduces cognitive load and human error, offering a scalable solution for the evolving needs of pharmacy education and clinical decision-making. Future developments could include advanced features such as drug interaction checks and multilingual support, further expanding its potential for global use.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Pharmaceutical_Calculator
  topic: keywords
subject: Pharmacoinformatics
  topic: keywords
subject: Web-Based_Application
  topic: keywords
subject: Usability_ Study
  topic: keywords
subject: Drug_Dosage_Calculation
  topic: keywords
creator: Mohamad Aprianto Paneo
creator: Multiani S Latif
creator: Teti Sutriyati Tuloli
creator: Nurain Thomas
creator: Lisa Efriani Puluhulawa
creator: Faradila Ratu Cindana Moo
rights: Copyright (c) 2025 Mohamad Aprianto Paneo, Multiani S. Latif, Teti Sutriyati Tuloli, Nurain Thomas, Lisa Efriani Puluhulawa, Faradila Ratu Cindana Moo (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 130
ending page: 136

The Potential of Microalgae from Bone River Gorontalo as an Antioxidant
type: item
description: Antioxidants are essential in preventing oxidative reactions caused by free radicals, which can lead to cellular damage. Microalgae are considered a promising natural source of antioxidants due to their bioactive metabolites. This study aimed to isolate and identify microalgae from the Bone River and assess their antioxidant activity. Microalgae isolation was conducted using the serial dilution method, while identification was based on microscopic morphological characteristics. The antioxidant activity was measured using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay with a UV Vis spectrophotometer. The data were analyzed statistically using ANOVA. The results identified three main isolates: MS 1 (Euglenophyta), MS 2 (Euglenophyta), and MS 3 (Chlorophyta). Qualitative tests confirmed positive antioxidant activity in all n-hexane extracts. The IC50 values obtained were 86.06 μg/mL (MS 1), 82.90 μg/mL (MS 2), and 98.06 μg/mL (MS 3), indicating strong antioxidant activity. ANOVA analysis (p < 0.05) revealed significant differences when compared to vitamin C as the control. In conclusion, microalgae isolated from the Bone River, particularly from the Euglenophyta and Chlorophyta groups, exhibit strong antioxidant potential and may serve as a valuable natural source for applications in the food and health industries.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: antioxidants
  topic: keywords
subject: Microalgae
  topic: keywords
subject: Bone River
  topic: keywords
creator: Mahdalena Pakaya
creator: Wiwit Uno
creator: Dizky Papeo
creator: Hudan Wijaya
creator: Rayyan Lasanudin
creator: Rahmatia Abdullah
rights: Copyright (c) 2025 Mahdalena Pakaya, Wiwit Zuriati Uno, Dizky Ramadani Putri Papeo, Hudan Ar’syifa Wijaya, Rayyan Zulfanafilah Lasanudin, Rahmatia Abdullah6 (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 144
ending page: 152

Pharmacokinetic and Bioavailability Profile of Hyptis capitata Jacq Flavonoids: A Scientific Perspective on Traditional
type: item
description: Hyptis capitata Jacq. (knobweed) is a traditional medicinal plant renowned for its bioactive flavonoid content, which exhibits antioxidant, anti-inflammatory, and analgesic activities. This study aimed to comprehensively characterize the pharmacokinetic and bioavailability profile of methanolic leaf extract flavonoids from H. capitata in rabbit (Oryctolagus cuniculus) plasma. An experimental pharmacokinetic design was employed, involving two rabbits orally administered with H. capitata methanolic extract at a dose of 832 mg and quercetin standard at 182 mg as a reference compound. Blood samples were collected via the marginal ear vein at 0, 0.5, 1, 2, 4, 6, 12, and 24 hours post-administration. Plasma was separated by centrifugation and analyzed using UV-Vis spectrophotometry at an optimal wavelength of 362 nm. The pharmacokinetic analysis revealed that H. capitata extract exhibited an absorption rate constant (Ka) of 0.621 h⁻¹, maximum plasma concentration (Cmax) of 19.76 µg/mL at a time to maximum concentration (Tmax) of 4.49 hours, elimination rate constant (K) of 0.034 h⁻¹, elimination half-life (t½) of 20.38 hours, apparent volume of distribution (Vd) of 3924.86 mL, clearance (Cl) of 133.4 mL/h, and area under the concentration–time curve (AUC) of 692.13 µg·h/mL. Compared to quercetin, H. capitata extract demonstrated slower absorption, lower Cmax, and prolonged elimination, indicating extended systemic exposure and the potential for sustained pharmacological effects. These findings provide important insights into the pharmacokinetic behavior of H. capitata flavonoids, supporting their relevance in modern phytopharmacology and the evidence-based development of traditional medicine applications.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Hyptis_capitata_Jacq
  topic: keywords
subject: Pharmacokinetics
  topic: keywords
subject: Bioavailability
  topic: keywords
subject: Flavonoids
  topic: keywords
subject: Traditional_Medicine
  topic: keywords
creator: Widy Susanti Abdulkadir
creator: Marsyanda Usman
creator: Dizky Ramadani Putri Papeo
rights: Copyright (c) 2025 Widy Susanti Abdulkadir, Marsyanda Usman, Dizky Ramadani Putri Papeo3 (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 177
ending page: 182

Formulation and Physical Evaluation of Ethanol Gel Extract of Okra Fruit (Abelmoschus esculentus L. Moench) From Parepare City
type: item
description: The use of herbal plants as alternative active ingredients in topical pharmaceutical preparations is growing, along with the increasing trend of using natural-based medicines. Okra fruit (Abelmoschus esculentus L. Moench) is known to contain active compounds such as flavonoids, alkaloids, and phenols that have antioxidant and anti-inflammatory activities, so it has the potential to be used in topical gel formulations. This study aims to formulate a gel preparation from ethanol extract of okra fruit from Parepare City and evaluate its physical characteristics, including organoleptic tests, pH, homogeneity, and spreadability. The extract was obtained through the reflux method using 70% ethanol and formulated in four concentration variations: 0%, 5%, 10%, and 15%. Physical evaluation was carried out during four cycles of extreme temperature storage. The results showed that all formulas had good organoleptic stability, with minimal changes in shape, color, and aroma. The pH value was within the physiological range of the skin, although there was a slight decrease at higher extract concentrations. The formula with a concentration of 5% showed the best stability in terms of pH, homogeneity, and spreadability, so it can be considered as the optimal formula for the development of herbal- based topical gels.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Okra Fruit
  topic: keywords
subject: Topical gel
  topic: keywords
subject: Ethanol extract
  topic: keywords
subject: Formulation
  topic: keywords
subject: Physical evaluation
  topic: keywords
creator: Fitriana Bunyanis
creator: Satheesh Babu
rights: Copyright (c) 2025 Fitriana Bunyanis, Satheesh Babu (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-30
publication date: 2025-09-30
starting page: 140
ending page: 143

Toxic Effects of Prenylated Flavone Compounds from the Chloroform Fraction of Kaledang (Artocarpus Lanceifolius Roxb.) Stem Bark In Vitro
type: item
description: Artocarpus is a genus in the Moraceae family that contains many prenylated flavonoid compounds. This study aimed to isolate prenylated flavonoid compounds from the chloroform fraction of the stem bark of Artocarpus lanceifolius Roxb. The extraction method used was multistage maceration, using solvents based on increasing polarity. Fractionation was performed using Vacuum Column Chromatography (VCCh), isolation using Radial Chromatography (CR), and structure elucidation using UV-Vis spectrophotometers, FTIR, H-NMR, C-NMR, and two-dimensional NMR (HMBC and HSQC). Toxicity testing was carried out using the Brine Shirimp Lethality Test (BSLT) using Artemia salina Leach. The isolation results indicated the presence of a prenylated flavone compound, Artobilosanthone. The toxicity test for Artobilosanthone showed an LC50 value of 3.36 µg/mL, making it highly toxic.
subject: Articles
  topic: section
subject: Articles
  topic: category
subject: Toxicity
  topic: keywords
subject: Artocarpus_Lanceifolius
  topic: keywords
subject: Flavon_terprenilasi
  topic: keywords
subject: LC50
  topic: keywords
creator: Hamsidar Hasan
creator: Mohammad Reski Manno
creator: Rifka Anggai
rights: Copyright (c) 2025 Hamsidar Hasan, Mohammad Reski Manno, Rifka A. Anggai (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 124
ending page: 129

Effectiveness Test of Ethanol Extract of Noni (Morinda citrifolia L.) Leaves as a Weight Loss Agent in Mice (Mus musculus)
type: item
description: Obesity is a disorder characterized by excessive fat accumulation in the body, often caused by overconsumption of food. Obese individuals are at higher risk of developing degenerative diseases. One plant known to reduce obesity is Noni (Morinda citrifolia L.) plant. This plant contains flavonoid compounds that act as pancreatic lipase inhibitors and appetite suppressants, thus aiding in weight loss. This research aims to determine the effectiveness of ethanol extract of Noni (Morinda citrifolia L.) leaves as a weight loss agent in mice (Mus musculus). This research employs an experimental method. The anti-obesity effect test was conducted using male mice, divided into five treatment groups: Group I as the Negative Control Group (Na CMC 1%), Group II as the Positive Control Group (Orlistat), Group III as Test Group 1 (Dose 20 mg/kg BW), Group IV as Test Group 2 (Dose 30 mg/kg BW), and Group V as Test Group 3 (Dose 40 mg/kg BW). The results indicate that the ethanol extract of Noni (Morinda citrifolia L.) leaves contains secondary metabolites such as flavonoids, saponins, and tannins. The results indicate that the best effectiveness was observed in the group with a 40 mg/kg BW dose, though it was greater than the positive control group (Orlistat 120 mg).
subject: Articles
  topic: section
subject: obesity
  topic: keywords
subject: Noni_(Morinda_citrifolia L.)
  topic: keywords
subject: Ethanol
  topic: keywords
subject: Mice_(Mus_musculus)
  topic: keywords
creator: Faramita Hiola
creator: Julianty akuba
creator: Andini buta
rights: Copyright (c) 2025 Faramita Hiola, Julianty akuba, Andini buta (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-30
publication date: 2025-09-30
starting page: 137
ending page: 139

Connecting Family Support with Self-Care for People with Diabetes Mellitus
type: item
description: Diabetes Mellitus (DM) is a chronic disease that requires long-term management. Family support plays an important role in helping DM patients perform self-care. The purpose of this study was to determine the relationship between family support and self-care in people with diabetes mellitus. Method: This study used a quantitative approach with a cross-sectional design. The study population was 147 diabetes mellitus patients, with a sample of 60 respondents selected using the Slovin Formula. Data were collected through questionnaires and analyzed using the Chi-Square test. Results: The analysis showed a significant relationship between family support and self-care in people with diabetes mellitus (P-value = 0.001). Patients who received high family support tended to be more disciplined in controlling their diet, doing physical activity, maintaining personal hygiene, and complying with medication. Conclusion: Family support has a significant relationship with self-care abilities in people with diabetes mellitus. Therefore, health workers need to involve families in diabetes management programs to increase effectiveness patient care.
subject: Articles
  topic: section
subject: Original Research
  topic: category
subject: Support family
  topic: keywords
subject: Self Care
  topic: keywords
subject: Diabetes Melitus
  topic: keywords
creator: Asnuddin Asnuddin
creator: Regidor III Dioso
rights: Copyright (c) 2025 Asnuddin Asnuddin, Regidor III Dioso (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-29
publication date: 2025-09-29
starting page: 119
ending page: 123

HUBUNGAN PERAN ORANG TUA DENGAN KECEMASAN ANAK SAAT DI RAWAT DI RUMAH SAKIT UMUM DAERAH OTANAHA KOTA GORONTALO
type: item
description: Hospitalisasi pada anak dapat menyebabkan kecemasan dan stres. Kecemasan pada anak disebabkan oleh tidak adanya kehadiran dan dukungan penuh dari orang tua, khawatir dengan prosedur medis, lingkungan yang baru, tindakan invasif dari petugas kesehatan. Maka dari itu peran orang tua diharapkan dapat memberikan dukungan penuh pada anak dan membantu mengurangi rasa cemas pada anak. Tujuan penelitian ini adalah untuk mengetahui hubungan peran orang tua dengan kecemasan anak saat di rawat di RSUD Otanaha Kota Gorontalo. Desain penelitian termasuk penelitian kuantitatif dengan metode cross- sectional. Populasi dalam penelitian ini yaitu semua anak yang sedang menjalani perawatan selama di RSUD Otanaha Kota Gorontalo. Teknik pengambilan sampel secara Accidental sampling dengan jumlah 176 responden. Pengumpulan data menggunakan instrumen HARS (Hamilton Anxiety Rating Scale). Hasil penelitian menunjukkan adanya hubungan antara peran orang tua dan tingkat kecemasan anak saat di rawat di RSUD Otanaha Kota Gorontalo dengan menggunakan uji chi-square didapatkan nilai p-value = 0,000 (p<0,05). Kesimpulannya semakin baik peran orang tua, maka semakin ringan kecemasan yang dirasakan anak saat hospitalisasi. Saran bagi peneliti selanjutnya diharapkan dapat mengembangkan variabel lain, agar hasil yang diperoleh dapat memberikan gambaran yang lebih utuh mengenai faktor-faktor yang memengaruhi tingkat kecemasan anak selama dirawat di rumah sakit. Hospitalization in children can cause anxiety and stress. Anxiety in children is caused by the absence of parental presence and support, concerns about medical procedures, a new environment, and invasive procedures by healthcare workers. Therefore, parents are expected to provide full support to their children and help reduce their anxiety. The purpose of this study was to determine the relationship between parental roles and children's anxiety during hospitalization at Otanaha Regional Hospital, Gorontalo City. The study design was quantitativ…
subject: Articles
  topic: section
subject: Anak, Kecemasan, Peran orang tua
  topic: keywords
creator: Maryam putri Ismail
creator: Ita Sulistiani
creator: Rini Wahyuni Mohamad
rights: Copyright (c) 2025 Maryam putri Ismail, Ita Sulistiani, Rini Wahyuni Mohamad (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-25
publication date: 2025-09-25

Pengaruh ROM Terhadap Kejadian Fatigue Pada Pasien Hemodialisa
type: item
description: Hemodialisa menjadi terapi utama untuk mempertahankan hidup lebih lama dan berkualitas pada penderita gagal ginjal kronis namun memiliki dampak negatif terhadap pasien baik secara fisik maupun psikologis. Keluhan fisik yang sering dialami pasien adalah fatigue (lemah, lelah, letih). Latihan ROM dapat meningkatkan sirkulasi darah, mengurangi kelelahan dan meningkatkan energi secara keseluruhan. Penelitian ini bertujuan untuk mengetahui pengaruh range of motion (ROM) terhadap kejadian fatigue pada pasien hemodialisa di RSUD Dr. M.M Dunda Limboto. Metode penelitian ini menggunakan jenis penelitian kuantitatif menggunakan desain penelitian quasi experimental dengan rancangan pretest-postest with control group design. Sampel yang digunakan dalam penelitian ini adalah pasien hemodialisa dengan keluhan fatigue di RSUD Dr. M.M Dunda Limboto berjumlah 30. Analisa data menggunakan uji independent sample t-test. Hasil penelitian didapatkan terdapat pengaruh range of motion terhadap penurunan kejadian fatigue pada pasien hemodialisa di RSUD Dr. M.M Dunda Limboto dengan menggunakan uji independent sample t-test didapatkan nilai p=0,000 (<0,05). Diharapkan hasil penelitian ini dapat digunakan sebagai pertimbangan dalam pemberian terapi komplementer pada pasien hemodialisa.
subject: Articles
  topic: section
subject: Original Research
  topic: category
subject: Hemodialisa, Fatigue, Range of Motion
  topic: keywords
creator: Nur Fatiya Atuna
creator: Herlina Jusuf
creator: Gusti Pandi Liputo
rights: Copyright (c) 2025 Nur Fatiya Atuna, Herlina Jusuf, Gusti Pandi Liputo (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-17
publication date: 2025-09-17

GAMBARAN TINGKAT PENGETAHUAN TENTANG BAHAYA MEROKOK PADA PASIEN TB PARU DI PUSKESMAS KOTA SELATAN
type: item
description: Kasus TB di Indonesia merupakan kasus tertinggi ke-2 di dunia setelah India. TB paru merupakan penyakit yang memiliki beberapa faktor risiko, berupa gaya hidup, sistem kekebalan yang lemah, riwayat kontak, kondisi lingkungan dan salah satunya adalah kebiasaan merokok. Orang yang merokok lebih rentan terhadap infeksi TBC karena daya tahan tubuhnya menurun, terutama di paru-paru, gangguan yang signifikan akibat asap rokok. Sehingga diperlukannya pengetahuan tentang bahaya merokok terhadap pasien TB Paru. Penelitian ini bertujuan untuk mengetahui gambaran tingkat pengetahuan tentang bahaya merokok terhadap pasien TB Paru di Puskesmas Kota Selatan. Desain penelitian ini menggunakan desain survei deskriptif. Populasi dalam penelitian ini yaitu seluruh penderita TB Paru yang berada di wilayah Puskesmas Kota Selatan yang berjumlah 100 orang, dan yang menjadi sampel yaitu berjumlah 50 responden, yang diperoleh dengan menggunakan teknik Accidental Sampling. Hasil penelitian yang dilakukan di Puskesmas Kota Selatan dari total 50 responden, diperoleh responden dengan pengetahuan rendah sejumlah 0 responden (0%), pengetahuan sedang sebanyak 38 responden (76%), dan responden dengan pengetahuan tinggi sejumlah 12 responden (24%). Kesimpulannya sumber informasi dan pengalaman yang diperoleh, dapat mempengaruhi pengetahuan tentang bahaya merokok pasien TBC. Perlu dilakukan pendekatan personal melalui konseling individu untuk pasien TB paru yang masih merokok. Serta memberikan semangat kepada anggota keluarga pasien dalam edukasi untuk mendorong pasien berhenti merokok.
subject: Articles
  topic: section
creator: Klaudiya Ras Huwolo
creator: Ita Sulistiani
creator: Gusti Pandi Liputo
rights: Copyright (c) 2025 Klaudiya_Ras_Huwolo Huwolo (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-11
publication date: 2025-09-11

HUBUNGAN ILLNESS PERCEPTION DENGAN KUALITAS HIDUP PADA PENDERITA DIABETES MELITUS TIPE II DI WILAYAH KERJA PUSKESMAS KABILA
type: item
description: Diabetes melitus tipe II dapat menyebabkan komplikasi serius hingga kematian, yang berdampak pada kualitas hidup pasien dan dipengaruhi oleh persepsi individu terhadap keparahan, durasi, dan dampak penyakit dalam kehidupan sehari-hari. Tujuan dalam penelitian ini adalah mengetahui apakah adanya hubungan illness perception dengan kualitas hidup penderita diabetes melitus tipe II di wilayah kerja Puskesmas Kabila. Metode penelitian menggunakan desain penelitian kuantitatif deskriptif korelasi dengan pendekatan cross sectional. Populasi dalam penelitian ini berjumlah 391 responden dengan besar sampel sebanyak 198 responden menggunakan teknik cluster sampling dan simple random sampling. Instrumen penelitian menggunakan kuesioner Brief Illness Perception Question (BIPQ) dan Diabetes Quality Of Life (DQOL). Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara illness perception dengan kualitas hidup pada penderita diabetes melitus tipe II di wilayah kerja Puskesmas Kabila dengan nilai p-value = < 0,05 menggunakan uji korelasi chi square. Dengan adanya penelitian ini diharapkan bagi penderita diabetes melitus tipe II dapat memahami penyakit, pengelolaan, dan pengobatannya. Sehingga membentuk illness perception positif yang berdampak pada peningkatan kualitas hidup melalui edukasi, dukungan medis, dan gaya hidup sehat.
subject: Articles
  topic: section
subject: Original Research
  topic: category
subject: Illness Perception, Kualitas Hidup, Diabetes Melitus Tipe II
  topic: keywords
creator: Isti Lihawa
creator: Sri Andriani Ibrahim
creator: Gusti Pandi Liputo
rights: Copyright (c) 2025 Isti Lihawa, Sri Andriani Ibrahim, Gusti Pandi Liputo (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-17
publication date: 2025-09-17

Gambaran Pengetahuan Perawat Tentang Penatalaksanaan Pertolongan Pertama Pada Kecelakaan Lalu Lintas Di Puskesmas Kota Gorontalo
type: item
description: Kecelakaan lalu lintas merupakan masalah kesehatan masyarakat diseluruh dunia sehingga dalam memberikan pertolongan pertama pada korban kecelakaan dipengaruhi pengetahuan perawat mengenai penatalaksanaan pertolongan pertama. Kasus kecelakaan di Kota Gorontalo mengalami peningkatan yaitu 300 kasus data pasien kecelakaan lalu lintas. Penelitian ini bertujuan untuk mengetahui gambaran pengetahuan perawat tentang penatalaksanaan pertolongan pertama pada kecelakaan lalu lintas di Puskesmas Kota Gorontalo. Penelitian ini merupakan jenis penelitian kuantitatif menggunakan metode penelitian deskriptif. Populasi terdiri dari seluruh perawat yang bekerja di Puskesmas Kota Selatan, Puskesmas Kota Tengah, Puskesmas Kota Utara, Puskesmas Kota Barat, Puskesmas Hulonthalangi, Puskesmas Dumbo Raya, dan Puskesmas Dungingi. Adapun pengambilan sampel dengan metode non probability sampling dengan cara total sampling berjumlah 90 responden. Instrumen penelitian menggunakan kuesioner. Hasil penelitian menunjukkan bahwa gambaran pengetahuan perawat tentang penatalaksanaan pertolongan pertama pada kecelakaan lalu lintas di Puskesmas Kota Gorontalo yang kategori pengetahuan baik sebanyak 81 orang (90%) dan kategori pengetahuan cukup sebanyak 9 orang (10%). Dengan demikian, dapat disimpulkan bahwa pengetahuan perawat tentang penatalaksanaan pertolongan pertama pada kecelakaan lalu lintas di Puskesmas Kota Gorontalo menunjukkan sebagian besar dalam kategori pengetahuan baik sebanyak 81 orang (90%).
subject: Articles
  topic: section
subject: Pengetahuan,
  topic: keywords
subject: Pertolongan Pertama
  topic: keywords
subject: Kecelakaan Lalu Lintas
  topic: keywords
creator: Denadi Nur Nabila
creator: Zuhriana K Yusuf
creator: Zulkifli B Pomalango
rights: Copyright (c) 2025 Denadi Nur Nabila (Author) https://creativecommons.org/licenses/by/4.0
date: 2025-09-11
publication date: 2025-09-11